A Life-Extension Drug for Big Dogs Is Getting Closer to Reality

In early studies, Loyal dosed 130 research dogs with its investigational drug. Halioua says the company has shown that it can reduce IGF-1 levels in large dogs to those seen in medium-size dogs. Two dogs had loose stools for a day or two after receiving the injection, but beyond that, Halioua says, no major side […]

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The FDA Approves Weight Loss Drug Zepbound, a Wegovy and Ozempic Rival

The blockbuster weight loss drug Wegovy has a new rival. Today, the US Food and Drug Administration approved a new drug for weight management called Zepbound, made by American pharmaceutical company Eli Lilly. The weekly injectable drug is meant for adults who are overweight or obese and have at least one weight-related condition, such as […]

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A Patient May Be Free of HIV, Thanks to This Drug

A sixth person, dubbed the “Geneva patient,” may be free of HIV after receiving a stem cell transplant intended to treat another disease—his cancer. The man, who was diagnosed with HIV in 1990, continues to have no detectable virus in his blood 20 months after stopping medication to control the infection. So far, five people […]

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Ticks and the Diseases They Carry Are Spreading. Can This Drug Stamp Them Out?

Back to the study. The Connecticut group chose a site where they could monitor a small, contained deer herd: a peninsula jutting into Long Island Sound where the property surrounding a decommissioned power plant is returning to a wild state. They deployed a feeder that would regularly scatter a small amount of corn—enough to dope […]

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The One-Shot Drug That Keeps on Dosing

Today they use lab robots to fill the capsules, and they are working to automate the entire process, which they call Pulsed, for Particles Uniformly Liquified and Sealed to Encapsulate Drugs. McHugh believes that this automation cuts costs and makes the tech scalable. Thanks to minor tweaks to the capsule recipe, the Pulsed particles rupture […]

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«Zombie drug», le nouveau fléau qui frappe les Etats-Unis de plein fouet – Libération

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A Critical New Drug Is Coming—Unless Agriculture Gets There First

In the intensive care ward of Radboud University Medical Center, a sprawling hospital in the southeastern Netherlands, Paul Verweij was worried. The physician-scientist was accustomed to dealing with very sick patients; as chair of medical microbiology, his job was to identify dire pathogens so the right treatments could be prescribed. One group of patients had the […]

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Hope on the Front Lines of the Drug Overdose Crisis

I read that OnPoint requires around $4.5 million per year to operate around-the-clock. How difficult or easy has it been to get the funding you need?  Very difficult. We’ve been staying afloat by fundraising, having the support of a number of amazing individuals and a few foundations. The part of our work that is looked […]

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The Last Drug That Can Fight Gonorrhea Is Starting to Falter

To an unfamiliar eye, the press release from the Massachusetts Department of Public Health two weeks ago looked pretty routine. Its language was a little unnerving, maybe, but phrased carefully: Analysts had discovered a resident with a strain of gonorrhea that showed “reduced response to multiple antibiotics,” but that person—and a second with a similar infection—had […]

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Drug Shortages Aren’t New. The Tripledemic Just Made You Look

Shortages persist because of complex structural problems. Take, for instance, one that the pandemic briefly made visible: the reality that many American medications are manufactured somewhere else, at the end of long supply chains. In some cases, the raw materials, known as active pharmaceutical ingredients, or API, come from offshore, primarily India and China. In others, the […]

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The Next Great Overdose-Reversing Drug Might Already Exist

Critics say the Schedule I classification is heavy-handed, based on fear rather than evidence. “It bypasses science,” says Maritza Perez, a director at the Drug Policy Alliance, a non-profit focused on drug policy reform. Frustrated by this blanket ban, and eager to develop new overdose treatments, a growing number of scientists, doctors, and other researchers […]

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Big Pharma Says Drug Prices Reflect R&D Cost. Researchers Call BS

At the end of September, a spot of good news: Relyvrio, a new drug for treating amyotrophic lateral sclerosis—or ALS, a neurological disorder without a cure—was approved in the United States. The ALS community rejoiced; the drug’s authorization was described as a “long-sought victory for patients.”  But the next day, the price of the medicine […]

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How a ‘Living Drug’ Could Treat Autoimmune Disease

In lupus, a type of autoimmune disease, the body’s natural defense system can’t tell the difference between its own cells and foreign ones, so it mistakenly attacks its own tissues and organs. The attackers are molecules called autoantibodies, which turn against the body instead of protecting it from invaders, like normal antibodies do. They trigger […]

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This Follicle-Hacking Drug Could One Day Treat Baldness

“I think it’s a realistic vision,” says Maria Kasper, associate professor of cell and molecular biology at the Karolinska Institute in Sweden. However, she emphasizes that it’s too early to say whether Plikus’ findings will lead to a new treatment for hair loss and notes that alternative therapeutic approaches are being developed as well. Turn […]

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Martin Shkreli Is Back With a Web3 Drug Discovery Platform

Martin Shkreli—the notorious ex-pharmaceutical executive fresh from prison after his 2017 fraud conviction—announced his latest, eyebrow-raising venture this week: the creation of a blockchain-based Web3 drug discovery platform that traffics in his own cryptocurrency, MSI, aka Martin Shkreli Inu. The platform, still in the early development phase, is called Druglike, according to a press release […]

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